2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-133798
    Sorafenib N-oxide
    Sorafenib N-oxide is an active metabolite of sorafenib (HY-10201). Sorafenib N-oxide is a linear-mixed inhibitor of microsomal CYP3A4, with a Ki of 15 μM.
    Sorafenib N-oxide
  • HY-109583S
    4-Oxofenretinide-d4
    4-Oxofenretinide-d4 (4-Oxo-4-HPR-d4) is deuterium labeled 4-Oxofenretinide. 4-Oxofenretinide (4-Oxo-4-HPR) is a metabolite of Fenretinide (HY-15373). 4-Oxofenretinide induces cell growth inhibition in ovarian, breast, and neuroblastoma tumor cell lines. 4-Oxofenretinide causes a marked accumulation of cells in G2-M. 4-Oxofenretinide induces cancer cell apoptosis through caspase-9.
    4-Oxofenretinide-d<sub>4</sub>
  • HY-135731R
    4-Methylamino antipyrine (Standard)
    4-Methylamino antipyrine (Standard) is the analytical standard of 4-Methylamino antipyrine. This product is intended for research and analytical applications. 4-Methylamino antipyrine is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic agent and can be used for pain and fever. 4-Methylamino antipyrine has analgesic, antipyretic, and relatively weak antiinflammatory properties.
    4-Methylamino antipyrine (Standard)
  • HY-132242R
    DL-Sulforaphane N-acetyl-L-cysteine (Standard)
    Pipemidic acid (trihydrate) (Standard) is the analytical standard of Pipemidic acid (trihydrate). This product is intended for research and analytical applications. Pipemidic acid trihydrate, a derivative of Piromidic acid, is an antibacterial agent. Pipemidic acid trihydrate inhibits DNA gyrase. Pipemidic acid trihydrate is active against gram-negative bacteria including Pseudomonas aeruginosa as well as some gram-positive bacteria. Pipemidic acid trihydrate can be used for the research of intestinal, urinary, and biliary tract infections.
    DL-Sulforaphane N-acetyl-L-cysteine (Standard)
  • HY-G0012
    Netupitant metabolite Monohydroxy Netupitant
    Monohydroxy Netupitant is the metabolite of Netupitant, which is a highly selective NK1 receptor antagonist.
    Netupitant metabolite Monohydroxy Netupitant
  • HY-128379R
    Labetalone hydrochloride (Standard)
    Labetalone (hydrochloride) (Standard) is the analytical standard of Labetalone (hydrochloride). This product is intended for research and analytical applications. Labetalone hydrochloride is an impurity of Labetalol. Labetalol is an orally active adrenoceptor blocking agent which is a competitive antagonist at both alpha- and beta-adrenoceptor sites.
    Labetalone hydrochloride (Standard)
  • HY-150339
    AB-INACA
    AB-INACA is a metabolite of AB-CHMINACA.
    AB-INACA
  • HY-W741839
    Aripiprazole N,N-Dioxide
    Aripiprazole N,N-dioxide is a metabolite of the atypical antipsychotic aripiprazole (HY-14546). It is formed from aripiprazole via oxidation.
    Aripiprazole N,N-Dioxide
  • HY-138291
    Ethoxyquin dimer
    		98.70%
    Ethoxyquin dimer is a dimer of Ethoxyquin (HY-B1425). Ethoxyquin dimer is an antioxidant. Ethoxyquin dimer can more readily accumulate in liver and adipose tissue compared with Ethoxyquin. Ethoxyquin above 10 mg/kg shows hepatotoxicity in mice.
    Ethoxyquin dimer
  • HY-W740216
    N-Demethyl Mifepristone
    N-Demethyl Mifepristone (RU 42633) is an active metabolite of Mifepristone (HY-13683). The affinities of N-Demethyl Mifepristone to the glucocorticoid receptor is 61% compared with 100% for Mifepristone.
    N-Demethyl Mifepristone
  • HY-122508
    Hydroxyebastine
    Hydroxyebastine is an Ebastine (HY-B0674) (a histamine H1-receptor antagonist) metabolite. Hydroxyebastine is metabolized to Carebastine (HY-121356) by CYP2J2 and CYP3A4.
    Hydroxyebastine
  • HY-W741886
    5-Methoxy-N-isopropyl tryptamine
    		Control
    5-Methoxy-N-isopropyl tryptamine is a tryptamine. 5-Methoxy-N-isopropyl tryptamine is a metabolite of 5-methoxy DiPT.
    5-Methoxy-N-isopropyl tryptamine
  • HY-B1417R
    Nortriptyline hydrochloride (Standard)
    Nortriptyline (hydrochloride) (Standard) is the analytical standard of Nortriptyline (hydrochloride). This product is intended for research and analytical applications. Nortriptyline (Desmethylamitriptyline) hydrochloride, the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline hydrochloride is a potent autophagy inhibitor and has anticancer effects.
    Nortriptyline hydrochloride (Standard)
  • HY-W699533
    4-Hydroxy valsartan
    4-Hydroxy valsartan is a metabolite of Valsartan (HY-18204). 4-Hydroxy valsartan regulates the expression of platelet surface receptors and inhibits conventional plasma or whole blood collagen induced platelet aggregation. 4-Hydroxy valsartan has antiplatelet activity.
    4-Hydroxy valsartan
  • HY-114686
    (R)-γ-Valerolactone
    (R)-γ-Valerolactone is a precursor of antihypertensive compounds. (R)-γ-Valerolactone can also be used in the research of biodegradable plastics and biofuels.
    (R)-γ-Valerolactone
  • HY-128669R
    Abemaciclib metabolite M2 (Standard)
    Abemaciclib metabolite M2 (Standard) is the analytical standard of Abemaciclib metabolite M2. This product is intended for research and analytical applications. Abemaciclib metabolite M2 (LSN2839567) is a metabolite of Abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC50s of 1.2 and 1.3 nM, respectively. Anti-cancer activity[1][2].
    Abemaciclib metabolite M2 (Standard)
  • HY-129443
    Deacetylcephaloglycin
    Deacetylcephaloglycin is the active metabolite of Cephaloglycin (HY-16137). Deacetylcephaloglycin is a degradation product of Cephaloglycin that eliminates the 3-acetyl group in acidic medium and can be further degraded to Deacetylcephaloglycin lactone. Deacetylation is the rate-determining step in the degradation of Cephaloglycin to lactone.
    Deacetylcephaloglycin
  • HY-G0010
    Netupitant metabolite N-desmethyl Netupitant
    N-desmethyl Netupitant is a metabolite of Netupitant, which is an antiemitic drug.
    Netupitant metabolite N-desmethyl Netupitant
  • HY-168354
    Desmethylflutiazepam
    Desmethylflutiazepam (N-Desmethylfludiazepam) is a metabolite of various benzodiazepine compounds.
    Desmethylflutiazepam
  • HY-119223
    Desmethylmirtazapine
    Desmethylmirtazapine is an active metabolite of Mirtazapine that has antidepressant effects.
    Desmethylmirtazapine
Cat. No. Product Name / Synonyms Application Reactivity